CBD has also been shown to have neuroprotective properties in cell cultures as well as in animal models of several neurodegenerative diseases, including Alzheimer’s, xii, xi, xstrokes, xv glutamate toxicity, xvi multiple sclerosis (MS), xs Parkinson’s disease, xviii and neurodegeneration caused by alcohol abuse.xx Nabiximols (trade name Sativex), which contains THC and CBD in roughly equal proportions, has been approved throughout most of Europe and in a number of other countries for the treatment of spasticity associated with MS. It has not been approved in the United States, but clinical trials are ongoing, and two recent studies have reported that they have reduced the severity of spasticity in MS patients.xx, xxi There have been limited clinical trials to assess the potential efficacy of CBD for the other indications highlighted; However, a recent double-blind trial trial in patients with Parkinson’s disease found the CBD improved quality-of-life scores.xxii
CBD and THC are the two main compounds in the marijuana plant and they are the only two cannabinoids that have been well characterized to date. Many strains of marijuana are known for having multiple levels of THC and high-CBD strains are less common; However, with the medical community paying attention to the therapeutic effects of CBD, that is beginning to change.
Furthermore, THC and CBD oils also differ in the nature and effect of their Cannabinoid content. Cannabinoids typically bind to receptor sites located in the brain, called CB-1, and various parts of the human body called CB-2. But different cannabinoids produce different effects depending on which type of receptor they bind to. THC is mostly binding to receptors in the brain, but CBD unlocks the receptors scattered throughout the body, making it more useful for healing properties.
Cannabis ruderalis is a native native to Russia that flowers earlier and is able to withstand harsher conditions than Cannabis sativa and Cannabis indica. It is the hardiest of the three, but it is relatively poor in terms of cannabinoids as ruderalis has a lower THC content than either sativa or indica.
Chronic stress can kill your quality of life, so stressed-out folks are always looking for proven ways to change this reality. Cannabis oil has the ability to both release pleasure hormones and relax the mind. It reduces stress and allows calming and peace to take over the body. Chemical components of cannabis, called cannabinoids, activate specific receptors found throughout the body to produce pharmacologic effects, especially in the central nervous system and the immune system.
For example, CB1 receptors send signals that regulate senses, while cannabinoids that interact with CB2 receptors can at the same time affect gastrointestinal response and peripheral nervous system sensitivity.
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In fact, one of the most studied uses for CBD is in treating neurological disorders like epilepsy and multiple sclerosis. Although research in this area is still relatively new, several studies have shown promising results.
The extraction solvents showed comparable efficiency for extracting terpenes, with the notable exception of naphtha. While this solvent generally extracted terpenes less efficiently than the other solvents, several terpenes could not be detected at all in the naphtha extract.
Research reveals that CBD can be an effective treatment with a wide range of natural health properties, including anti-inflammatory, anti-seizure, anti-anxiety, and anti-tumor properties. Studies are still ongoing about the other positive characteristics of the CBD, but it has been proven that the use of this compound is relatively safe.
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Leighty EG, Fentiman AF Jr, Foltz RL. Long-maintained metabolites of delta9- and delta8-tetrahydrocannabinols identified as novel fatty acid conjugates. Res Commun Chem Pathol Pharmacol 1976; 14 (1): 13-28. View abstract.
E, Spiro A, Wong A, Spencer J, Huynh T, Gunasekaran N, Karl T, Long LE, Huang XF, Liu K, Arnold JC, McGregor IS (November 2011). “Cannabidiol potential Δ⁹-tetrahydrocannabinol (THC) behaviors and alters THC pharmacokinetics during acute and chronic treatment in adolescent rats”. Psychopharmacology. 218 (2): 443-457. do: 10.1007
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Concern about the dangers of marijuana abuse led to the banning of cannabinoids for medicinal use in the United States and many other countries in the 1930s and 1940s. It took decades until they came to be considered again as compounds of therapeutic value, and even now their uses are very restricted.
There are several good reasons to choose CBD over Cannabis oil and how it is made to alleviate health conditions, but none is more important than the legality. While the issue of marijuana recreational law, marijuana, and even cannabis therapeutic substances is in flux in the U.S., there are some key points to understand.
Bhattacharyya S, Fusar-Poli P, Borgwardt S, et al. Modulation of mediotemporal and ventrostriatal function in humans by Delta9-tetrahydrocannabinol: neural basis for the effects of Cannabis sativa on learning and psychosis. Arch Gen Psychiatry 2009; 66: 442-51. View abstract.
Applying cannabis oil to the skin stimulates the shredding of dead skin cells and promotes fresh and glowing appearance. Cannabinoids are responsible for lipid production, so they can help with regulating conditions such as dry skin or acne – and may be added to your home remedies for acne.
Early preclinical findings also suggest that CBD may have therapeutic value as a treatment of substance use disorders. CBD reduced the rewarding effects of morphinexxxviii and reduced cue-induced heroin seekingxxxix in animal models. A few small clinical trials have examined the CBD and
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Dalterio S, Steger R, Mayfield D, Bartke A. Early cannabinoid exposure to neuroendocrin and reproductive influences in mice: II. Postnatal effects. Pharmacol Biochem Behav 1984; 20: 115-23. View abstract.
Massi P, Valenti M, Vaccani A, et al. 5-Lipoxygenase and anandamide hydrolase (FAAH) mediate the antitumor activity of cannabidiol, non-psychoactive cannabinoid. J Neurochem 2008; 104 (4): 1091-100. View abstract.
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In addition, some cannabinoids interact synergistically, producing unique effects that are not found when using them individually. For example, CBD inhibits THC’s psychotropic effects when the two are taken together. However, CBD does this (and produces many other effects) without directly interacting with the cannabinoid receptors. At first, scientists thought there was a third type of CB receptor just for Cannabidiol, but the answer was far more interesting and revealing.
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